Retrovirus-like particles containing modified envelope...

Details Retrovirus-like particles containing modified envelope... Retrovirus-like particles containing modified envelope...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/21 (2006.01) A61K 39/42 (2006.01) C07K 14/16 (2006.01) C12N 7/01 (2006.01) C12N 15/49 (2006.01) C12N 15/85 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2098029

Self-assembled, non-replicating, non-infectious retrovirus-like particles contain a chimeric envelope glycoprotein. The envelope glycoprotein comprises a first retroviral amino acid sequence which is substantially homologous with the native retrovirus amino acid sequence and a second retroviral amino acid sequence which is a heterologous amino acid sequence inserted into the first amino acid sequence. Such particles, which may comprise a retroviral surface glycoprotein sequence of HIV-1 or HTLV-1 inserted into the C2 conserved region of an HIV-1 isolate, generally elicit an immune response to at least the heterologous amino acid sequence, preferably both the first and second amino acid sequences.

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