C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 14/145 (2006.01) C07K 14/15 (2006.01) C12N 5/10 (2006.01) C12N 15/867 (2006.01)
Patent
CA 2365655
Retroviral vector particle producing cells are provided, wherein the cell (a) has greater than 5 stably integrated copies of a retroviral vector construct; (b) produces greater than 10 infectious recombinant retroviral vector particles per cell per day; and (c) produces replication incompetent retroviral vector particles.
L'invention concerne des cellules produisant des particules de vecteur rétroviral, lesquelles cellules (a) comprennent plus de 5 copies stablement intégrées d'une construction de vecteur rétroviral; (b) produisent plus de 10 particules infectieuses de recombinaison de vecteur rétroviral par cellule et par jour; et (c) produit des particules de vecteur rétroviral incapables de se répliquer.
Bodner Mordechai
Chang Stephen M. W.
de Polo Nicholas J.
Sauter Sybille L.
Sheridan Philip Lee
Borden Ladner Gervais Llp
Chiron Corporation
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