C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2385628
The subject invention concerns new methods which make it possible, for the first time, to grow functional islet-producing stem cells (IPSCs), islet progenitor cells (IPCs) and IPC-derived islets (IdIs) in in vitro cultures. The subject invention also concerns the use of the in vitro grown IPSCs, IPCs and/or IdIs for implantation into a mammal for in vivo therapy of diabetes. The subject invention further concerns a process of using the implanted cells for growing a pancreas-like structure in vivo that has the same functional, morphological and histological characteristics as those observed in normal pancreatic endocrine tissue. The ability to grow these cells in vitro and pancreas-like structures in vivo opens up important new avenues for research and therapy relating to diabetes.
L'invention concerne de nouveaux procédés qui permettent pour la première fois de cultiver des cellules souches insulaires fonctionnelles (IPSC), des cellules insulaires progénitrices (IPC) et des îlots dérivés D'IPC (IdI) dans des cultures in vitro. Elle concerne également l'emploi de IPSC, IPC et/ou IdI cultivés in vitro pour les implanter chez un mammifère pour une thérapie in vitro. Elle concerne en outre une technique d'utilisation des cellules implantées pour cultiver in vivo une structure de type pancréas présentant les mêmes caractéristiques fonctionnelles, morphologiques et histologiques que celles observées dans un tissu endocrinien pancréatique normal. L'aptitude à cultiver ces cellules in vitro et des structures de type pancréas in vivo ouvre de nouvelles perspectives importantes en matière de recherche et de thérapie relatives aux diabètes.
Cornelius Janet G.
Peck Ammon B.
Ramiya Vijayakumar K.
Ixion Biotechnology Inc.
Sim & Mcburney
University Of Florida Research Foundation
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