Reversal of multi-drug resistance by tetraarylethylenes

Details Reversal of multi-drug resistance by tetraarylethylenes Reversal of multi-drug resistance by tetraarylethylenes

A - Human Necessities

61

K

A61K 31/535 (2006.01) A61K 31/135 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2129143

Certain tetraarylethylenes reverse drug resistance in multi-drug resistant tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tu- mors from certain origins.

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