A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/107 (2006.01) A61K 9/20 (2006.01)
Patent
CA 2468788
The invention can be summarized as follows. The present invention provides a reverse-micellar delivery system for enhanced absorption of an agent of interest across biological membranes such as the gastro-intestinal tract of mammals. The reverse-micelles comprise at least one ionic amphipathic compound, and at least one polar active agent ionizable in aqueous or physiological media. The delivery system facilitates transportation of the agent across the gastro-intestinal tract or other membranes and enhances thein- vivo release and availability of the agent(s) of interest within a fluid environment.
Cette invention concerne un système d'administration micellaire inverse servant à renforcer l'absorption d'un agent d'intérêt dans des membranes biologiques telles que le tractus gastro-intestinal de mammifères. Les micelles inverses comprennent au moins un composé amphipathique ionique et au moins un agent actif polaire pouvant être ionisé en milieu aqueux ou physiologique. Le système d'administration de la présente invention facilite le transport de l'agent dans le tractus gastro-intestinal ou d'autres membranes et renforce la libération in vivo et la disponibilité du ou des agents d'intérêt dans un environnement fluidique.
Gowling Lafleur Henderson Llp
Macgregor Alexander
LandOfFree
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