Reverse protein

Details Reverse protein Reverse protein

A - Human Necessities

61

K

A61K 38/19 (2006.01) C07K 14/525 (2006.01)

Patent

CA 2707850

A protein which is composed N-terminally of one or several C-terminal parts of the amino acid sequence of the mature tumour necrosis factor and C-terminally of one or several N--terminal parts of the amino acid sequence of the mature tumour necrosis factor, which activates epithelial ion channels and improves the lung function and which can be used for the manufacture of medicaments for the treatment of diseases associated with the lung function, such as oedemas.

L'invention concerne une protéine, dont l'extrémité N-terminale se compose d'une ou de plusieurs parties C-terminales de la séquence d'aminoacide du facteur de nécrose tumorale mature, l'extrémité C-terminale se composant d'une ou de plusieurs parties de la séquence d'aminoacide du facteur de nécrose tumorale mature. Ladite protéine active des canaux ioniques épithéliaux et améliore la fonction pulmonaire. Ladite protéine peut s'utiliser pour produire des médicaments servant à traiter des pathologies associées à la fonction pulmonaire, comme l'oedème.

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