Reverse-turn mimetics and methods relating thereto

Details Reverse-turn mimetics and methods relating thereto Reverse-turn mimetics and methods relating thereto

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/495 (2006.01) C07D 498/04 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2286733

Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetics of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.

On décrit des composés à conformation contrainte qui imitent la structure secondaire de régions à rotation inverse de protéines et de peptides biologiquement actifs. Ces mimétiques à rotation inverse sont utiles dans de nombreux domaines, y compris en tant qu'agents de diagnostic et de thérapie. On décrit également des bibliothèques contenant les mimétiques à rotation inverse de cette invention, ainsi que des procédés de criblage de ces derniers utiles pour identifier des éléments biologiquement actifs.

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