Reverse-turn mimetics and methods relating thereto

Details Reverse-turn mimetics and methods relating thereto Reverse-turn mimetics and methods relating thereto

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 519/00 (2006.01) C07F 7/10 (2006.01) C07F 9/6561 (2006.01) C07K 5/078 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2235138

Conformationally constrained compounds of formula (I) which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetics of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.

Cette invention se rapporte à des composés de conformation contrainte, représentés par la formule (I), qui imitent la structure secondaire des régions à rotation inverse de peptides et de protéines biologiquement actifs. Ces agents mimétiques à rotation inverse ont une utilité dans une large gamme de domaines, y compris comme agents diagnostiques et thérapeutiques. Des bibliothèques contenant ces agents mimétiques à rotation inverse, ainsi que des procédés pour cribler ces agents en vue d'identifier des éléments biologiquement actifs sont également décrits.

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