Reverse-turn mimetics and methods relating thereto

Details Reverse-turn mimetics and methods relating thereto Reverse-turn mimetics and methods relating thereto

A - Human Necessities

61

K

A61K 31/4985 (2006.01) A61K 31/519 (2006.01) A61K 31/551 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2375952

Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, such as multiple sclerosis, atherosclerosis, asthma and inflammatory bowel disease.

L'invention concerne des composés de conformation contrainte, qui imitent la structure secondaire des régions à rotation inverse de peptides et de protéines biologiquement actifs. Lesdits mimétiques à rotation inverse sont utiles pour le traitement de pathologies induites par l'adhésion de cellules, telles que la sclérose en plaques, l'athérosclérose, l'asthme ou les affections intestinales inflammatoires.

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