G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 35/08 (2006.01) B01F 13/08 (2006.01) G01N 35/00 (2006.01) G01N 35/10 (2006.01)
Patent
CA 2083322
Sample liquid analysis apparatus and method are provided, and comprise the formation and supply to a conduit of a stream of successive sample liquid test packages, and the repeated bi-directional displacement of the sample liquids test package stream in the conduit through one, or a plurality of spaced, sample liquid analysis apparatus which are operatively associated with the sample liquid conduit to provide for repeated, time-spaced analyses in turn of the sample liquids in each of the sample liquid test packages. Each of the sample liquid test packages comprises a first segment of a sample liquid and a first reagent liquid, and a second segment of a second reagent liquid spaced from the first segment by a different fluid in the test package. The conduit includes a portion which is operable to combine the respective first and second segments of each of the sample liquid test packages upon the flow of the same therethrough to commence the sample and reagent liquids reaction for sample liquid analysis; and the, or at least one of the, sample liquid analysis apparatus is disposed upstream in the conduit of this conduit portion to enable independent analyses of the respective first and second segments of the sample liquid test packages in turn prior to the combination thereof. Precisely operable, positive displacement pumping, operatively associated with the conduit inlet, or with both the conduit inlet and outlet and, in that event, precisely coupled to provide for differential pumping, is utilized for the formation and supply of the sample liquid test packages in turn to the conduit to form the sample liquids test package stream therein, and for the repeated bi- directional displacement of that stream in the conduit. An isolation liquid which is immiscible with the sample and reagent liquids, and which preferentially wets the walls of the conduit to the substantial exclusion of those liquids, is introduced to the conduit to minimize the adherence of the sample liquids thereto, thereby minimizing sample liquid carryover, and maximizing sample liquids analyses accuracy.
Gherson Paul G.
Zabetakis George
Corporation Bayer
Macrae & Co.
Miles Inc.
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