Reversible inhibition of sperm receptor synthesis for...

Details Reversible inhibition of sperm receptor synthesis for... Reversible inhibition of sperm receptor synthesis for...

A - Human Necessities

61

K

A61K 31/17 (2006.01) A61K 31/505 (2006.01) A61P 15/16 (2006.01)

Patent

CA 2659979

Methods and pharmaceutical compositions are disclosed for reversibly inhibiting sperm receptor activity in animals. Nicarbazin, its derivatives and modifications which retain pharmacological activity are shown to inhibit activity of zona pellucida proteins and concomitant synthesis and/or assembly of the sperm receptor on the oocyte surface necessary for fertilization. Nicarbazin is easily administered, for example by simple addition to feed of an animal and is and non-toxic to the animals, providing a safe and efficient means for controlling populations of mammals and avian species.

L'invention concerne des procédés et des compositions pharmaceutiques pour inhiber de façon réversible l'activité des récepteurs de sperme chez les animaux. Il a été prouvé que la nicarbazine, ses dérivés et modifications conservant l'activité pharmacologique inhibent l'activité des protéines de la zone pellucide et la synthèse et/ou l'assemblage simultanés du récepteur de sperme sur la surface des oocytes nécessaires à la fécondation. La nicarbazine est facilement administrée, par exemple par simple addition à l'alimentation d'un animal et est non toxique pour les animaux, fournissant des moyens sûrs et efficaces pour contrôler les populations de mammifères et d'espèces aviaires.

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