C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01) A61P 3/10 (2006.01) A61P 25/28 (2006.01) A61P 31/20 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C07D 473/16 (2006.01) C07D 473/18 (2006.01) C07D 473/34 (2006.01) C07D 473/40 (2006.01)
Patent
CA 2584209
The present invention provides compositions and methods for reversibly inhibiting S~adenosyl-L-homocysteine (SAH) hydrolase. The compounds of the present invention can be used in combination with an anti-hemorrhagic viral infection agent, an immunosuppressant, a homocysteine lowering agent, or an anti-neoplasm agent. The compositions and methods of the present invention can be used for the prevention and treatment of hemorrhagic virus infection, autoimmune diseases, autograft rejection, neoplasm, hyperhomocysteineuria, cardiovascular disease, stroke, Alzheimer's disease, or diabetes.
Cette invention concerne des compositions et des procédés permettant d'inhiber de manière réversible la S-adénosyl-L-homocystéine (SAH) hydrolase. Les composés de cette invention peuvent être utilisés en combinaison avec un agent infectieux viral antihémorragique, un immunosuppresseur, un agent abaissant le taux d'homocystéine, ou un agent anti-néoplasique. Les compositions et procédés de cette invention peuvent servir à la prévention et au traitement d'une infection virale hémorragique, de maladies auto-immunes, du rejet d'autogreffes, d'un néoplasme, de l'hyperhomocystéinémie, d'une maladies cardiovasculaire, d'un accident vasculaire cérébral, de la maladie d'Alzheimer ou du diabète.
Fetherstonhaugh & Co.
General Atomics
LandOfFree
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