C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/48 (2006.01) A61K 9/50 (2006.01) A61K 38/48 (2006.01) C12N 9/68 (2006.01) C12N 9/72 (2006.01) C12N 9/76 (2006.01) C12N 9/96 (2006.01) A61K 38/00 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01)
Patent
CA 2389337
The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent.
L'invention concerne une composition fibrinolytique utile comme agent thérapeutique destinée à être administrée à un patient souffrant d'une occlusion thrombotique. Dans un aspect de l'invention, la composition fibrinolytique contient une sérine protéase acidifiée inactivée de manière réversible, laquelle est sensiblement dépourvue d'un activateur du plasminogène, un tampon à faible capacité de tamponnage et éventuellement, un agent stabilisant. Dans un autre aspect de l'invention, cette composition fibrinolytique contient une plasmine acidifiée inactivée de manière réversible sensiblement dépourvue d'un activateur du plasminogène, un tampon à faible capacité de tamponnage et éventuellement, un agent stabilisant.
Colandene James
Jiang Shan
Novokhatny Valery
Zimmerman Thomas P.
Borden Ladner Gervais Llp
Corporation Bayer
Talecris Biotherapeutics Inc.
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