Rfrp-containing prolactin secretion regulatory agent

Details Rfrp-containing prolactin secretion regulatory agent Rfrp-containing prolactin secretion regulatory agent

A - Human Necessities

61

K

A61K 38/22 (2006.01) A61K 45/00 (2006.01) A61P 5/10 (2006.01) A61P 15/00 (2006.01) A61P 15/08 (2006.01) A61P 15/10 (2006.01) C07K 14/47 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) C12Q 1/02 (2006.01) G01N 33/12 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2401946

A polypeptide having effects of promoting and inhibiting the secretion of prolactin. Owing to these effects, this polypeptide is useful as a prolactin secretion promoter in preventives and remedies for various diseases in which prolactin secretion participates (for example, hypoovarianism, spermatic underdevelopment, menopause and hypothyroidism), and as a prolactin secretion inhibitor in preventives and remedies for various diseases in which prolactin secretion participates (for example, pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, hyperpituitarism, Chairi-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome and spermatogenesis disorder.

La présente invention concerne un polypeptide capable de favoriser et d'inhiber la sécrétion de prolactine. Ainsi, ce polypeptide s'avère utile en tant qu'activateur de sécrétion de prolactine dans des prophylactiques et des thérapeutiques destinés à différentes maladies dans lesquelles la sécrétion de prolactine est impliquée (par exemple l'hypoovarianisme, le sous-développement spermatique, la ménopause et l'hyperthyroïdie), et en tant qu'inhibiteur de sécrétion de prolactine dans des prophylactiques et des thérapeutiques destinés à différentes maladies dans lesquelles la sécrétion de prolactine est impliquée (par exemple la tumeur hypophysaire, la tumeur du diencéphale, les troubles menstruels, les maladies auto-immunes, le prolactinome, la stérilité, l'impuissance, l'aménorrhée, la lactorrhée, l'hyperpituitarisme, le syndrome de Chairi-Frommel, le syndrome de Argonz-del Castilo, le syndrome de Forbes-Albright, le lymphome, le syndrome de Sheehan, et les troubles de la spermatogenèse.

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