Rgd (arg-gly-asp) coupled to (neuro)peptides

Details Rgd (arg-gly-asp) coupled to (neuro)peptides Rgd (arg-gly-asp) coupled to (neuro)peptides

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) C07K 5/09 (2006.01) C07K 5/10 (2006.01) C07K 7/08 (2006.01) C07K 7/22 (2006.01) C07K 14/575 (2006.01) C07K 14/595 (2006.01) C07K 14/655 (2006.01) C07K 14/75 (2006.01) C07K 14/78 (2006.01)

Patent

CA 2407514

The invention relates to compounds having a binding affinity for both the .alpha.v.beta.3 receptor and a(neuro)peptide receptor, in particular the somatostatin receptor, which compound comprises a first peptide part comprising at least once the amino acid sequence Arg-Gly-Asp, and a second peptide part coupled thereto, optionally via a linker, which second peptide part is a (neuro) peptide.

L'invention porte sur des composés ayant une affinité de liaison à la fois avec le récepteur alpha v beta 3 et un récepteur (neuro)peptidique, notamment le récepteur de la somatostatine. Ces composés comprennent une première partie peptidique comprenant au moins la séquence d'acides aminés Arg-Gly-Asp à laquelle est couplée une seconde partie peptidique couplée, éventuellement, par l'intermédiaire d'un lieur, cette seconde partie peptidique étant un (neuro)peptide.

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