Rhesus her2/neu, nucleotides encoding same, and uses thereof

Details Rhesus her2/neu, nucleotides encoding same, and uses thereof Rhesus her2/neu, nucleotides encoding same, and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/71 (2006.01) C12N 5/16 (2006.01) C12N 15/861 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2512365

Polynucleotides encoding rhesus monkey HER2/neu have been isolated, cloned and sequenced. The gene encoding the HER2/neu is commonly associated with the development of epithelial-derived human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the HER2/neu tumor-associated antigen, wherein aberrant HER2/neu expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector constructs carrying rhHER2/neu and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.

L'invention concerne les polynucléotides codant pour les HER2/neu de singe rhésus, isolés, copiés et séquencés. Le gène codant pour HER2/neu est généralement associé au développement des carcinomes humains dérivés de l'épithélium. La présente invention fournit des compositions et des procédés pour obtenir ou améliorer l'immunité au produit protéique exprimé par la tumeur associée à l'antigène HER2/neu, où l'expression anormale de HER2/neu est associée à un carcinome ou à son développement. Cette invention fournit particulièrement un vecteur adénoviral et des constructions de plasmides portant rhHER2/neu et révèle leur utilisation dans des en vaccins et des compositions pharmaceutiques pour éviter et traiter le cancer.

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