Rhesus monkey bombesin receptor subtype-3 (brs-3),...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2522172

A rhesus monkey bombesin receptor subtype-3 has been isolated, cloned and sequenced. This receptor is characteristic of the G-protein family of receptors. Isolated rhesus monkey bombesin receptor subtype-3 may be used to screen and identify novel bombesin receptor modulators that may contribute to the regulation of endocrine processes, metabolism, or the cell cycle. Such compounds may be used in the treatment of conditions that result from deregulated expression of bombesin receptor subtype-3.

On a isolé, cloné et séquencé un sous-type 3 du récepteur de la bombésine du rhésus macaque. Ce récepteur est caractéristique de la famille des récepteurs de la protéine G. Le sous-type 3 du récepteur de la bombésine du rhésus macaque isolé peut être utilisé pour cribler et pour identifier de nouveaux modulateurs du récepteur de la bombésine qui peuvent contribuer à la régulation des processus endocriniens, du métabolisme ou du cycle cellulaire. Ces composés peuvent être utilisés dans le traitement de pathologies qui résultent de l'expression dérégulée du sous-type 3 du récepteur de la bombésine.

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