Rheumatoid factor activity encoded by variant immunoglobulin...

Details Rheumatoid factor activity encoded by variant immunoglobulin... Rheumatoid factor activity encoded by variant immunoglobulin...

G - Physics

01

N

G01N 33/564 (2006.01) C07K 16/00 (2006.01) C07K 16/42 (2006.01)

Patent

CA 2066674

2066674 9105258 PCTABS00004 Diagnosis and therapy of inflammatory diseases is provided by detecting the presence of mutations in the framework regions of light chains of immunoglobulins. Particularly, a multiplicity of mutations in the framework region (3) at conserved sites is found to be associated with erosive arthritis. By detecting the presence of mutations in the nucleic acid or resulting encoded light chain, propensity for inflammatory diseases and prophylactic and therapeutic treatments is provided.

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