Rho kinase inhibitors

Details Rho kinase inhibitors Rho kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/517 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2700988

The present invention relates to inhibitors of ROCK1 and ROCK2, which may be selective for ROCK2, and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and/or ROCK2. Also provided are treatments combining inhibitors of ROCK1 and/or ROCK2 with statins.

La présente invention concerne des inhibiteurs de ROCK1 et R0CK2 qui peuvent être sélectifs vis-à-vis de R0CK2 et des procédés de modulation des propriétés pharmacocinétiques et/ou pharmacodynamiques de ces composés. L'invention concerne également des procédés d'inhibition de ROCK1 et/ou de R0CK2. Elle concerne également des traitements qui combinent des inhibiteurs de ROCK1 et/ou de de R0CK2 avec des statines.

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