C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61P 3/04 (2006.01) C07D 403/14 (2006.01)
Patent
CA 2755095
The present invention relates to inhibitors of ROCK1 and ROCK2, which may be selective for ROCK2, and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and/or ROCK2. Also provided are treatments combining inhibitors of ROCK1 and/or ROCK2 with statins.
La présente invention concerne des inhibiteurs de la ROCK1 et de la ROCK2, qui peuvent être sélectifs de la ROCK2, et des procédés de modulation des propriétés pharmacocinétiques et/ou pharmacodynamiques de tels composés. L'invention concerne également des procédés d'inhibition de la ROCK1 et/ou de la ROCK2. L'invention concerne en outre des traitements combinant les inhibiteurs de la ROCK1 et/ou de la ROCK2 avec des statines.
Bartolozzi Alessandra
Campbell Anthony
Cole Bridget
Foudoulakis Hope
Kirk Brian
Smart & Biggar
Surface Logix Inc.
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