Rhoc-based immunotherapy

A - Human Necessities – 61 – K

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Details

A61K 39/00 (2006.01) A61K 38/00 (2006.01) C07K 7/00 (2006.01)

Patent

CA 2710061

The present invention relates generally to the field of prophylaxis and therapy of metastatic cancer. In particular there is provided a protein; Ras Homology gene family, member C(RhoC) or peptide fragments thereof that are capable of eliciting anti-cancer immune responses. Specifically, the invention relates to use of RhoC or peptides derived thereof or RhoC specific T-cells for treatment of metastatic cancer. Hence, the invention in one aspect relates to RhoC specific T-cells adoptively trans- ferred or induced in vivo by vaccination as a treatment of cancer. Also the use of RhoC and immunogenic peptide fragments here- of in cancer treatment, diagnosis and prognosis is provided.

La présente invention concerne généralement le domaine de la prophylaxie et du traitement du cancer métastatique. En particulier, elle concerne une protéine de la famille de gènes d'homologie Ras, un élément C (RhoC) ou des fragments peptidiques de celle-ci, qui sont capables de provoquer des réponses immunitaires anti-cancer. Spécifiquement, l'invention concerne l'utilisation de la Rhoc ou des peptides dérivés de celle-ci ou de lymphocytes T spécifiques de la Rhoc pour le traitement du cancer métastatique. Donc, un aspect de l'invention concerne les lymphocytes T spécifiques de la RhoC, transférés par adoption ou induits in vivo par la vaccination, comme traitement du cancer. De même, l'invention concerne également l'utilisation de la RhoC et de ses fragments peptidiques immunogènes dans le traitement, le diagnostic et le pronostic du cancer.

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