Rhodanine derivative, process for preparing the same and...

Details Rhodanine derivative, process for preparing the same and... Rhodanine derivative, process for preparing the same and...

C - Chemistry, Metallurgy

07

D

167/208, 260/310

C07D 277/36 (2006.01) A61K 31/425 (2006.01) C07D 277/20 (2006.01) C07D 417/06 (2006.01)

Patent

CA 1241327

Abstract of the Disclosure A rhodanine derivative having the following general formula (I): Image (I) wherein R is a mono- or di-alkylamino group having 1 to 6 carbon atoms which may be substituted by a hydroxyl group; an alkenylamino group having 3 to 6 carbon atoms; a phenylamino group, the benzene ring of which may be substituted by a lower alkyl group, a lower alkoxyl group, phenyl group or a halogen atom; or a cyclic amino group which may contain in the ring an oxygen atom or a nitrogen atom to which a lower alkyl group is attached; or a nontoxic salt thereof. The rhodanine derivative has potent platelet aggregation inhibiting activity and aldose reductase inhibiting activity and therefore is useful as a therapeutic agent for diabetic complications.

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