Ribavirin granulate for producing coated tablets

Details Ribavirin granulate for producing coated tablets Ribavirin granulate for producing coated tablets

A - Human Necessities

61

K

A61K 31/7056 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2470342

The present invention relates to a method for the production of a ribavirin- containing granulate, comprising the production of a granulate solution, mixing of a binding agent with an isopropanol/water- or ethanol/water-mixture, stirring the granulate solution into a mixture of ribavirin-powder with a hydrophilic or swellable solid adjuvant, and sieving and drying the resulting granulate, which is characterised in that the portion of isopropanol or ethanol of the alcohol/water-mixture is between 65% to 85% by weight. Based on this granulate, a ribavirin-tablet can be produced that can be used for the treatment of diseases, such as HCV.

L'invention concerne un procédé pour la production d'un granulat contenant de la ribavirine. Le procédé selon l'invention comprend la production d'une solution de granulation par mélange d'agents liants avec un mélange isopropanol/eau ou éthanol/eau, l'incorporation de la solution de granulation dans un mélange de ribavirine en poudre avec un agent auxiliaire solide hydrophile ou gonflant, puis le criblage et le séchage du granulat ainsi obtenu. Le procédé selon l'invention est caractérisé en ce que la teneur en isopropanol ou en éthanol du mélange alcool/eau est comprise entre 65 et 85 % en poids. Il est possible de produire à partir du granulat selon l'invention un comprimé de ribavirine pouvant être utilisé pour le traitement d'affections telles que l'hépatite C.

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