Ribonucleotide reductase inhibitors

Details Ribonucleotide reductase inhibitors Ribonucleotide reductase inhibitors

C - Chemistry, Metallurgy

07

K

530/7.04, 167/10

C07K 7/06 (2006.01) C07K 1/06 (2006.01) C07K 7/08 (2006.01) C12Q 1/26 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1327869

RIBONUCLEOTIDE REDUCTASE INHIBITORS Abstract of Disclosure Disclosed herein are peptides of the formula Y-R1-R2-R3-R4-R5-R6-Z wherein R1 to R5 are designated amino acid residues; R6 is Phe or an amino acid residue derived from 2-amino-3-cyclohexylpropionic acid, 2-amino-3- (4-(lower alkoxy)phenyl) propionic acid or 2-amino- 3-(4-halophenyl)propionic acid; Y is Phe, desamino-Phe, (lower alkanoyl)-Phe, Tyr, desamino-Tyr or (lower alkanoyl)-Tyr, or Y is the decapeptide radical W-Val-R7-Ser-R8-R9-Thr-Glu-R10-Ser-Phe wherein W is hydrogen or lower alkanoyl and R7 to R10 are designated amino acids residues, or Y is a fragment of the decapeptide radical wherein from one to nine of the amino acid residues (i.e. Val to Ser) may be deleted serially from the amino terminus of the decapeptide radical; and Z is hydroxy, amino, lower alkylamino or di(lower alkyl)amino. The peptides inhibit mammalian ribonucleotide reductase and are indicated for preventing or ameliorating abnormal cell proliferation.

591372

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