Ribozyme analogs

Details Ribozyme analogs Ribozyme analogs

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C07F 9/02 (2006.01) C07J 1/00 (2006.01) C12N 9/22 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2204870

Disclosed are ribozyme analogs having the ability to endonucleolytically cleave a sequence of 3' to 5' linked ribonucleotides. The ribozyme analogs include a plurality of 3' to 5' covalently-linked nucleotides, and a rigid molecular linker having at least one non-nucleotidic molecule covalently linked to two of the nucleotides. Also disclosed are methods of preparing and utilizing the ribozyme analogs of the invention, and pharmaceutical formulations and kits containing such ribozyme analogs.

L'invention se rapporte à des analogues de ribozymes aptes à segmenter de manière endonucléolytique une séquence de ribonucléotides présentant une liaison terminaison 3' - terminaison 5'. Ces analogues de ribozymes comprennent une pluralité de nucléotides à liaison covalente terminaison 3' - terminaison 5', et un élément de liaison moléculaire rigide comprenant au moins une molécule non nucléotidique liée de façon covalente à deux des nucléotides. L'invention concerne également des procédés de préparation et d'utilisation des analogues de ribozymes précités, et des formulations pharmaceutiques et nécessaires contenant de tels analogues.

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