C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 39/29 (2006.01) C07H 21/02 (2006.01) C07K 14/08 (2006.01) C07K 14/16 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/70 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2066647
2066647 9104324 PCTABS00003 Ribozymes, sequences cleaving RNA, derived from sequences present in the hepatitis delta virus, have been engineered for greater specificity without increasing size. The specific ribozyme sequences are useful as reagents for cleaving RNA for experimental studies as well as antiviral therapies. Examples demonstrating the targeting of these sequences against HIV and Crohn's disease are described in detail. The sequences are also useful as diagnostics for the detection of hepatitis delta virus in tissue and fluid samples, as in blood banking, as well as in isolation and characterization of new viroids having ribozyme activity, using an RNA specific hybridization method. Based on analysis of the two domain structure of the hepatitis delta virus, it is possible to construct a vector for expression of non-hepatitis delta virus proteins in mammalian cells.
Goldberg Allan R.
Robertson Hugh D.
Bereskin & Parr
Ribozyme Pharmaceuticals Inc.
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