Ribozyme having a thermodynamically stable loop

Details Ribozyme having a thermodynamically stable loop Ribozyme having a thermodynamically stable loop

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C07H 21/02 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2139411

The present invention is to provide a polyribonucleotide having a thermodynamically stable loop structure and ribozyme activity, a DNA that codes for said polyribonucleotide, and so forth. The polyribonucleotide having the following structure can be listed as a specific example of the present invention: (b) Image Direct administration of the ribozyme polyribonucleotide of the present invention into the body enables a target polyribonucleotide in the body to be efficiently cleaved, thereby allowing it to be used as a carcinostatic drug, anti-AIDS drug and so forth.

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