C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/70 (2006.01) C07H 21/02 (2006.01) C12N 9/22 (2006.01) C12P 19/34 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2231685
As an effective therapy for restenosis, this invention provides ribozymes and ribozyme delivery systems useful to inhibit abnormal smooth muscle cell proliferation in vascular tissue. Methods of producing ribozymes and gene therapy utilizing these ribozymes also are provided. The ribozymes are especially targeted to cdc2-kinase PCNA, cyclin B1, lysyl oxidase or an extracellular matrix protein.
L'invention concerne un traitement efficace contre la resténose, utilisant des ribozymes et des systèmes d'administration de ceux-ci pour inhiber la prolifération anormale de cellules de muscles lisses dans les tissus vasculaires. L'invention concerne également des procédés pour produire des ribozymes et une thérapie génique utlisant ces ribozymes. Ces derniers sont notamment ciblés sur cdc2-kinase PCNA, cycline B1, lysyl oxydase ou une protéine matricielle extracellulaire.
Goldenberg Tsvi
Tritz Richard
Gowling Lafleur Henderson Llp
Immusol Inc.
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