Ribozyme therapy for the treatment of proliferative skin and...

Details Ribozyme therapy for the treatment of proliferative skin and... Ribozyme therapy for the treatment of proliferative skin and...

A - Human Necessities

61

K

A61K 31/713 (2006.01) A61P 17/00 (2006.01) A61P 27/02 (2006.01) C07H 21/00 (2006.01) C12N 9/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2388924

As an effective therapy for proliferative skin and eye diseases such as psoriasis and proliferative diabetic retinopathy, this invention provides ribozymes and ribozyme delivery systems which cleave RNA encoding cytokines involved in inflammation, matrix metalloproteinases, a cyclin, a cell-cycle dependent kinase, a growth factor, or a reductase.

L'invention concerne une thérapie efficace dirigée contre les maladies proliférantes de la peau et des yeux, telles que le psoriasis et la rétinopathie diabétique proliférante. Elle fait intervenir des ribozymes et des systèmes d'administration de ribozymes qui clivent l'ARN codant les cytokines impliquées dans l'inflammation, des métalloprotéinases matricielles, une cycline, une kinase dépendante du cycle cellulaire, un facteur de croissance ou une réductase.

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