Ribozymes used for restenosis prevention

Details Ribozymes used for restenosis prevention Ribozymes used for restenosis prevention

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 9/10 (2006.01) A61P 41/00 (2006.01) C12N 9/00 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2385228

The invention relates to a catalytically active RNA molecule that is directed to mRNA molecules that encode the cell cycle relevant proteins cyclin E or E2F1. The catalytically active RNA molecule is a hammerhead ribozyme that induces the inhibition of the cell cycle of vascular smooth muscle cells in order to prevent restenosis.

Molécule d'ARN à action catalytique, qui est dirigée contre des molécules d'ARNm codant pour les protéines cycline E ou E2F1 pertinentes pour le cycle cellulaire. Ladite molécule d'ARN à action catalytique est un ribozyme en tête de marteau qui induit l'inhibition du cycle cellulaire de cellules vasculaires de muscles lisses pour prévenir la resténose.

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