Rifamycin compounds

Details Rifamycin compounds Rifamycin compounds

C - Chemistry, Metallurgy

07

D

260/235.82

C07D 498/18 (2006.01) C07D 498/08 (2006.01)

Patent

CA 1083144

ABSTRACT OF THE DISCLOSURE Rifamycin compounds having high antibac- terial activity, comprising powder of yellow-orange color. Such compounds are obtained by reacting 3-amino-substituted-4-desosso-4-imino rifamycin S with aldehydes of formula X-CHO, wherein X is selected from the group consisting of hydrogen, alkyl having 1-5 car- bon atoms, carboxyl, formyl, phenyl, aromatic hydro- carbon-alkenyl having 8 carbon atoms, cycloalkyl having 6 carbon atoms, cycloalkenyl having 6 carbon atoms, al- kenyl having 3 carbon atoms, a heterocyclo selected from the group consisting of thienyl, furyl, pyridyl and 5,6-dihydro-2H-pyranyl, and substitution products of the above specified radicals having 1 or 2 radicals different there- from and selected from the group consisting of halogen, methyl, methoxyl, N,N-dimethylamino and carboxyl.

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