Rifamycin derivatives

Details Rifamycin derivatives Rifamycin derivatives

C - Chemistry, Metallurgy

07

D

260/235.82

C07D 498/18 (2006.01) C07D 498/22 (2006.01)

Patent

CA 1173030

ABSTRACT OF THE DISCLOSURE: Novel rifamycin derivatives having the formula : Image wherein Y is -H or -COCH3; R1 and R2 may be liner and branched alkyl having from 1 to 7 carbon atoms and alkenyl having 3 or 4 carbon atoms R2 may be also chloroalkyl having from 2 to 4 carbon atoms, cycloalkyl having from 3 to 7 carbon atoms in the ring, cycloalkylalkyl having from 3 to 6 carbon atoms in the ring, phenyl, bornyl, ary].alkyl hydrocarbon having 7 or 8 carbon atoms which may bc substitutcd with one halogen atom in the aryl group; and R1 and R2 along with the N atom to which they are bonded form an unsubstituted cyclic moiety having from 5 to 8 carbon atoms, a ciclic moiety having from 5 to 3 carbon atoms substituted with 1 or 2 methyl radicals, 4-alkylpiperazine, morpholine, 1,2,3,4-tetrahydroisoquinoline. These novel compounds are yellow-orange solids having high antibacterial activity which are obtained by reacting 3-amino-4-deoxo--4-imino rifamycin S which a chloroformiminio chloride.

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