Rifamycins from nocardia mediterranea

Details Rifamycins from nocardia mediterranea Rifamycins from nocardia mediterranea

C - Chemistry, Metallurgy

12

P

195/96, 260/235.

C12P 19/00 (2006.01) C07D 498/08 (2006.01)

Patent

CA 1054959

ABSTRACT A process for producing novel rifamycins useful as antibiotics and indentified as rifamycin P, rifamycin Q, rifamycin R and rifamycin U. The process comprises fermenting under aerobic conditions in the presence of as assimilable carbon source, an assimilable nitrogen source and essential min- eral salts a mutant Nocardia mediterranea strain. The strain is selected form Nocardia mediterranea ATCC 31064 (D-2), Nocardia mediterranea ATCC 31085 (MM 18-6) and Nocardia Mediterranea ATCC 310166 (M-36) and their equilavents. The fermentation is continued until the fermentation medium shows substantial antibiotic activity. The new rifamycins are recovered form the fermentation medium and then separated out s a single individual product.

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