Rifapentine hydrohalides

Details Rifapentine hydrohalides Rifapentine hydrohalides

C - Chemistry, Metallurgy

07

D

167/180, 260/235

C07D 498/08 (2006.01) A61K 31/495 (2006.01)

Patent

CA 1339215

The acid addition salts of rifapentine with hydrochloric and hydrobromic acid are obtained from rifapentine free bases and hydrohalic acid aqueous solutions. The crystallization from different organic solvents or precipitation from solvents by addition of non-solvents yield two distinct polymorphs and the amorphous form. The polymorphs show high stability drug storage and under the conditions usually employed for the formulation of the pharmaceutical dosage forms.

605232

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