Riluzole aqueous suspensions

Details Riluzole aqueous suspensions Riluzole aqueous suspensions

A - Human Necessities

61

K

A61K 9/10 (2006.01) A61K 47/34 (2006.01) A61P 21/00 (2006.01) A61K 31/428 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2748856

Physically and chemically stable aqueous suspensions of riluzole are disclosed together with the manufacturing methods thereof. Such aqueous suspensions comprise riluzole in particle form and at least a wetting agent, preferably a surfactant. Riluzole is in amounts from about 0.1% to about 20% w/v and has an average particle size lower than 200 µm; such suspensions are devoid of the known local (mouth) anaesthetic effects of riluzole.

L'invention concerne des suspensions aqueuses de riluzole physiquement et chimiquement stables et des procédés de fabrication correspondants. Ces suspensions aqueuses renferment du riluzole sous forme de particules et au moins un agent de mouillage, de préférence un tensioactif. Le riluzole est présent en quantités allant d'environ 0,1% à environ 20% (poids/volume) et présente une taille de particule moyenne inférieure à 200 µm; de telles suspensions sont dépourvues des effets anesthésiants locaux (bouche) connus du riluzole.

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