C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/226, 260/284
C07D 217/14 (2006.01) A61K 31/47 (2006.01) C07D 401/06 (2006.01) C07D 409/06 (2006.01)
Patent
CA 1333067
A compound, or a solvate or salt thereof, of formula (I): Image ( I) in which: RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring and R1 and R2 are independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl or C4-12 cycloalkylalkyl groups or together form a C2-8 branched or linear polymethylene or C2-6 alkenylene group optionally substituted with a hetero-atom; R3 is hydrogen, C1-6 alkyl, or phenyl, or R3 together with R1 forms a -(CH2)3- or -(CH2)4-, group; R4 and R5, which may be the same or different and may be attached to the same or different carbon atoms of the isoquinoline nucleus, are each hydrogen, halogen, hydroxy, C1-6 alkyl, aryl, or R4 together with R5 form a -(CH2)p- group, where p is an integer of from 1 to 5 and one or more of the -(CH2)- moieties is optionally substituted by a C1-6 alkyl group. R6 and R6a, which may be the same or different, are each hydrogen, C1-6 alkyl, -CH2OR6b, halogen, hydroxy, C1-6 alkoxy, C1-6 alkoxycarbonyl, thiol, C1-6 alkylthio, Image , -NHCOR6d, -NHSO2R6e, -CH2SO2NR6fR6g, in which each of R6b to R6g is independently hydrogen, C1-6 alkyl, aryl or aralkyl; with the proviso that R4, R5, R6 and R6a are not simultaneously hydrogen, is useful for the treatment of pain.
591455
Giardina Giuseppe
Vecchietti Vittorio
Borden Ladner Gervais Llp
Dr. Lo Zambeletti Spa.
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