Rm2 antigen (beta 1,4-galnac-disialyl-lc4) as prostate...

G - Physics – 01 – N

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G01N 33/53 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2559525

A novel carbohydrate antigen, .szlig.1,4-GalNAc-disialyl-Lc4, defined by monoclonal antibody RM2, is expressed in human prostate cancer, but not in benign prostate hypertrophy (BPH) or normal prostate gland. Monoclonal antibody RM2 or other antibodies with similar specificity are useful for diagnosis of prostate cancer by immunohistology of biopsy samples, specifications from a total prostatectomy, and quantitative determination of RM2 antigen in sera of patients.

Cette invention concerne .szlig.1,4-GalNAc-disialyl-Lc¿4, ?un nouvel antigène carbohydrate, défini par l'anticorps monoclonal RM2, qui est exprimé en cas de cancer de la prostate chez l'homme, mais pas en cas d'hypertrophie bénigne de la prostate (HBP) ou de prostate normale. L'anticorps monoclonal RM2 ou d'autres anticorps présentant des spécificités similaires peuvent être utilisés pour le diagnostic d'un cancer de la prostate par analyse immuno-histologique d'échantillons prélevés par biopsie, par spécification après une prostatectomie complète, et par mesure quantitative de l'antigène RM2 dans les sérums des patients.

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