C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01)
Patent
CA 2681406
Short oligonucleotides directed against the Apo-B100 gene are provided for modulating the expression of Apo-B100. Methods of using these compounds for modulation of Apo-B100 expression and for the treatment of diseases associated with Apo-B100 expression are provided. The oligonucleotides comprise deoxyribonucleosides and locked nucleic acids.
L'invention porte sur des oligonucléotides courts dirigés contre le gène de l'Apo-B100, pour la modulation de l'expression de l'Apo-B100. L'invention porte également sur des procédés d'utilisation de ces composés pour la modulation de l'expression de l'Apo-B100 et pour le traitement de maladies associées à l'expression de l'Apo-B100. Les oligonucléotides comprennent des désoxyribonucléosides et des acides nucléiques verrouillés.
Hansen Bo
Hansen Henrik Frydenlund
Rosenbohm Christoph
Straarup Ellen Marie
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Santaris Pharma A/s
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