C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C07K 14/77 (2006.01)
Patent
CA 2622583
Oligonucleotides directed against the Apo-B100 gene are provided for modulating the expression of Apo-B100. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the Apo-Bl00. Methods of using these compounds for modulation of Apo-Bl00 expression and for the treatment of diseases associated with either overexpression of Apo-Bl00, expression of mutated Apo-Bl00 or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.
L'invention concerne des oligonucléotides dirigés contre le gène Apo-B100 pour moduler l'expression de Apo-B100. Les compositions comprennent des oligonucléotides, en particulier, des oligonucléotides antisens ciblant des acides nucléiques qui codent pour Apo-Bl00. L'invention concerne également des méthodes d'utilisation de ces composés pour moduler l'expression de Apo-Bl00 et pour traiter des maladies associées t à la surexpression de Apo-Bl00 et/ou à l'expression de Apo-Bl00 muté ou les deux. Les maladies prises en exemple sont le cancer du poumon, du sein, du colon, de la prostate, du pancréas, du foie, de la thyroïde, du rein, du cerveau, des testicules, de l'estomac, de l'intestin, de la moelle épinière, des sinus, de la vessie, des voies urinaires ou des ovaires. Ces oligonucléotides peuvent être composés de désoxyribonucléosides et/ou d'un analogue d'acide nucléique tel que, par exemple, un acide nucléique bloqué (LNA).
Hansen Bo
Hansen Henrik Frydenlund
Rosenbohm Christoph
Straarup Ellen Marie
Westergaard Majken
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Santaris Pharma A/s
LandOfFree
Rna antagonist compounds for the inhibition of apo-b100... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Rna antagonist compounds for the inhibition of apo-b100..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Rna antagonist compounds for the inhibition of apo-b100... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1964224