C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01)
Patent
CA 2697970
Oligonucleotides directed against the FABP4 gene are developed for modulating the expression of FABP4 protein. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding FABP4. Methods of using these compounds for modulation of FABP4 expression and for the treatment of diseases associated with over expression of FABP4 are provided. Examples of such diseases are the metabolic syndrome, diabetes, atherosclerosis, and inflammatory states such as arthritis. The oligomer may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid (LNA) or a combination thereof.
L'invention concerne des oligonucléotides dirigés contre le gène FABP4, utiles dans la modulation de l'expression de la protéine FABP4. Des compositions contiennent des oligonucléotides, en particulier des oligonucléotides antisens, ciblant des acides nucléiques codant FABP4. L'invention concerne également des méthodes d'utilisation de ces composés dans la modulation de l'expression de FABP4 et dans le traitement de maladies associées à la surexpression de FABP4. Des exemples de ces maladies comprennent le syndrome métabolique, le diabète, l'athérosclérose et les états inflammatoires tels que l'arthrite. L'oligomère peut être composé de désoxyribonucléosides ou d'un analogue d'acide nucléique, tel qu'un acide nucléique bloqué, ou d'une combinaison de ceux-ci.
Mccullagh Keith
Nielsen Niels Fisker
Straarup Ellen Marie
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Santaris Pharma A/s
LandOfFree
Rna antagonist compounds for the modulation of fabp4/ap2 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Rna antagonist compounds for the modulation of fabp4/ap2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Rna antagonist compounds for the modulation of fabp4/ap2 will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1693102