C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01)
Patent
CA 2666191
The present invention provides compounds, compositions and methods for modulating the expression of PCSK9. In particular, this invention relates to oligomeric compounds, such as oligonucleotide compounds, which are hybridisable with target nucleic acids encoding PCSK9, and methods for the preparation of such oligomeric compounds. The oligonucleotide compounds have been shown to modulate the expression of PCSK9, and pharmaceutical preparations thereof and their use as treatment of hypercholesterolemia and related disorders are disclosed.
La présente invention concerne des composés, des compositions et des procédés pour moduler l'expression de PCSK9. En particulier, cette invention porte sur des composés oligomères, tels que des composés oligonucléotidiques hybridables avec des acides nucléiques cibles codant pour PCSK9, et sur des procédés pour la préparation de tels composés oligomères. Les composés oligonucléotidiques ont été montrés moduler l'expression de PCSK9. Sont également décrites des préparations pharmaceutiques à base de ces composés et leur utilisation en tant que traitement de l'hypercholestérolémie et de troubles associés.
Nielsen Niels Fisker
Straarup Ellen Marie
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Santaris Pharma A/s
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