Rna interference agents for therapeutic use

Details Rna interference agents for therapeutic use Rna interference agents for therapeutic use

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2638906

The invention features chemically modified small interfering RNAs (siRNAs) that are stable in vivo and retain the ability to form an A-form helix when in association with a target RNA. The features sÊRNA are effective therapeutics, particularly for targeting SODl.

L' invention concerne des petits ARN interférents chimiquement modifiés (siRNA) qui sont stables in vivo et conservent la capacité de former une hélice en forme de A lorsqu'ils sont associés à un ARN cible. Les siRNA selon l'invention sont des agents therapeutiques efficaces, notamment pour le ciblage de SODl.

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