C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2489174
The present invention relates to sequence and structural features of single- stranded (ss)RNA molecules required to mediate target-specific nucleic acid modifications by RNA-interference (RNAi), such as target mRNA degradation and/or DNA methylation.
L'invention concerne les caractéristiques séquentielles et structurelles de molécules d'ARN simple brin (ARNss) requises pour la médiation des modifications d'acides nucléiques spécifiques à la cible par interférence de l'ARN (ARNi),comme la dégradation d'ARNm cible et/ou la méthylation d'ADN.
Luehrmann Reinhard
Martinez Javier
Patkaniowska Agnieszka
Tuschl Thomas
Urlaub Henning
Max-Planck Gesellschaft Zur Foerderung Der Wissenschaften E.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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