Rna interference mediated inhibition of vascular endothelial...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/11 (2006.01) A01N 43/04 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2537085

This invention relates to compounds, compositions, and methods useful for modulating VEGF and/or VEGFR gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of VEGF and/or VEGFR gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double- stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of VEGF and/or VEGFR genes.

L'invention concerne des composés, des compositions et des méthodes utiles pour la modulation de l'expression du gène VEGF et/ou de VEGFR au moyen de molécules d'acide nucléique à interférence courte (siNA). L'invention concerne également des composés, des compositions et des méthodes qui permettent de moduler l'expression et l'activité d'autres gènes qui jouent un rôle dans les voies de l'expression et/ou l'activité de VEGF et/ou de VEGFR par interférence d'ARN (ARNi) au moyen de petites molécules d'acide nucléique. L'invention concerne notamment des petites molécules d'acide nucléique, telles que des molécules d'acide nucléique à interférence courte (siNA), d'ARN à interférence courte (siRNA), d'ARN à double brin (dsRNA), de micro-ARN (miRNA) et d'ARN court en épingle à cheveux (shRNA) ainsi que des méthodes permettant de moduler l'expression des gènes de VEGF et/ou de VEGFR.

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