Rna-selective hybridization reagent and use of the same

Details Rna-selective hybridization reagent and use of the same Rna-selective hybridization reagent and use of the same

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2722479

Provided is a nucleoside derivative which has a high affinity for RNA. Use is made of a nucleoside derivative represented by either formula (1) or formula (2). (In formulae (1) and (2), Z represents a carbon atom or a nitrogen atom; R1 represents a hydrogen atom or a hydroxyl-protecting group; and R2 represents a hydrogen atom or a phosphodiester group). (see formula 1)

La présente invention concerne un dérivé de nucléoside qui possède une grande affinité pour l'ARN. Un dérivé de nucléoside représenté par la formule (1) ou la formule (2) est utilisé. (Dans les formules (1) et (2), Z représente un atome de carbone ou un atome d'azote; R1 représente un atome d'hydrogène ou un groupe de protection hydroxyle; et R2 représente un atome d'hydrogène ou un groupe phosphodiester).

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