C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01) C07H 19/067 (2006.01) C07H 19/167 (2006.01)
Patent
CA 2735251
The present invention relates to novel phosphoramidites, A-n-bz, C-n-bz, C-n- ac, G-n-ac and U are produced with an HPLC purity of greater than 98% and 31P NMR purity greater than 99%. A novel process of reverse 5'.fwdarw. 3' directed synthesis of RNA oligomers has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.
La présente invention concerne de nouveaux phosphoramidites, A-n-bz, C-n-bz, C-n-ac, G-n-ac et U qui sont produits avec une pureté par CLHP supérieure à 98 % et une pureté par RMN au 31P supérieure à 99 %. Un nouveau procédé de synthèse antisens dirigée de 5' ? 3' doligomères dARN a été développé et présenté. Lutilisation de ce procédé a montré une qualité de synthèse dARN élevée avec une efficacité de couplage approchant les 99 %.
Bajpai Satya P.
Pandey Divya
Srivastava Naveen P.
Srivastava Suresh C.
Chemgenes Corporation
Gowling Lafleur Henderson Llp
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