Rna virus vaccines and methods

Details Rna virus vaccines and methods Rna virus vaccines and methods

A - Human Necessities

61

K

A61K 39/12 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2646623

The invention is a vaccine, and method of vaccination, against RNA viruses, including RNA viruses in the family Flaviviridae, which includes for example West Nile Virus, Yellow fever virus, Dengue fever virus, Hepatitis C virus, Pestiviruses, Bovine viral diarrhea virus, and Classical Swine fever virus, wherein the vaccine comprises the RNA virus or immunogenic portions thereof, which have been treated with and rendered non-pathogenic by a phenothiazine dye and visible light, the phenothiazine dyes, including, but not limited to, Methylene Blue (MB), Methylene Green, 1 -methyl MB, 1,9-dimethyl MB, Azure A, Azure B, Azure C, thionine, and toluidine blue, or by squalene. The invention includes novel strains of WNV for use in producing a vaccine, and novel primers and their use in recognizing and amplifying all of or portions of the WNV genome for diagnosing WNV infections, for quality control of the vaccine, or for identifying the presence of WNV in blood or blood products.

L'invention concerne un vaccin et un procédé de vaccination contre des virus à ARN, y compris des virus à ARN de la famille des flaviviridés, qui comprend par exemple le virus du Nil occidental (VNO), le virus de la fièvre jaune, le virus de la dengue, le virus de l'hépatite C, les pestivirus, le virus de la diarrhée virale bovine et le virus de la peste porcine classique, ledit vaccin comprenant le virus à ARN ou des parties immunogènes de celui-ci qui ont été traitées et rendues non pathogènes au moyen d'un colorant phénothiazinique et de lumière visible, les colorants phénothiaziniques comprenant non limitativement le bleu de méthylène (MB), le vert de méthylène, le 1-méthyl-MB, le 1,9-diméthyl-MB, l'azur A, l'azur B, l'azur C, la thionine et le bleu de toluidine, ou au moyen de squalène. L'invention concerne de nouvelles souches du VNO destinées à être utilisées pour produire un vaccin, ainsi que de nouvelles amorces et leur utilisation pour reconnaître et amplifier tout ou partie du génome du VNO dans le but de diagnostiquer des infections par le VNO, contrôler la qualité du vaccin ou identifier la présence du VNO dans le sang ou les produits sanguins.

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