Rnai inhibition of ctgf for treatment of ocular disorders

Details Rnai inhibition of ctgf for treatment of ocular disorders Rnai inhibition of ctgf for treatment of ocular disorders

A - Human Necessities

61

K

A61K 48/00 (2006.01)

Patent

CA 2591611

RNA interference is provided for inhibition of connective tissue growth factor mRNA expression in ocular disorders involving CTGF expression. Ocular disorders involving aberrant CTGF expression include glaucoma, macular degeneration, diabetic retinopathy, choroidal neovascularization, proliferative vitreoretinopathy and wound healing. Such disorders are treated by administering interfering RNAs of the present invention.

Selon l'invention, l'interférence ARN permet l'inhibition de l'expression ARNm du facteur de croissance du tissu conjonctif (CTGF) dans des troubles oculaires impliquant l'expression du CTGF. Les troubles oculaires impliquant une expression CTGF aberrante comprennent le glaucome, la dégénérescence maculaire, la rétinopathie diabétique, la néovascularisation choroïdienne, la vitréorétinopathie proliférative et les troubles de la cicatrisation. Ces troubles sont traités par administration d'ARN interférents selon l'invention.

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