Rnai-mediated inhibition of hif1a for treatment of ocular...

Details Rnai-mediated inhibition of hif1a for treatment of ocular... Rnai-mediated inhibition of hif1a for treatment of ocular...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7105 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2632595

RNA interference is provided for inhibition of HIFlA mRNA expression for treating patients with ocular angiogenesis, particularly for treating retinal edema, diabetic retinopathy, sequela associated with retinal ischemia, posterior segment neovascularization (PSNV), and neovascular glaucoma, and for treating patients at risk of developing such conditions.

L'ARN interférent est mis en oeuvre pour inhiber l'expression de l'ARNm de HIF1A, en vue de traiter des patients atteints d'angiogenèse oculaire, notamment pour traiter l'oedème rétinien, la rétinopathie diabétique, des séquelles associées à l'ischémie rétinienne, à la néovascularisation du segment postérieur (PSNV), au glaucome néovasculaire, et pour traiter des patients susceptibles de développer ces affections.

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