Rnai-mediated inhibition of ocular hypertension targets

Details Rnai-mediated inhibition of ocular hypertension targets Rnai-mediated inhibition of ocular hypertension targets

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01)

Patent

CA 2595790

RNA interference is provided for inhibition of ocular hypertension target mRNA expression for lowering elevated intraocular pressure in patients with open- angle glaucoma or ocular hypertension. Ocular hypertension targets include carbonic anhydrase II, IV, and XII; 1- and 2 adrenergic receptors; acetylcholinesterase; Na+/K+-ATPase; and Na-K-2Cl cotransporter. Ocular hypertension is treated by administering interfering RNAs of the present invention.

La présente invention se rapporte à une interférence ARN visant à inhiber l'expression ARNm de cibles d'hypertension oculaire, afin de diminuer la pression intraoculaire élevée chez des patients atteints de glaucome à angle ouvert ou d'hypertension oculaire. Les cibles d'hypertension oculaire sont notamment l'anhydrase carbonique II, IV et XII ; les récepteurs adrénergiques .beta.1 et .beta.2 ; l'acétylcholinestérase ; la Na+/K+-ATPase ; et le cotransporteur Na-K-2Cl. L'hypertension oculaire est traitée par l'administration d'ARN interférents selon l'invention.

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